In this study, we enrolled five different cancer types (non-small cell lung cancer, gastric cancer, hepatocellular carcinoma, pancreatic ductal adenocarcinoma, and renal cell carcinoma) and performed a meta-analysis of data from 728 patients to assess the significance of PYCR1 expression in cancer prognosis. This evidence concerns the gene PYCR1 and hereditary clear cell renal cell carcinoma.