KRT19 and hepatocellular carcinoma: It has been reported that recurrence-free survival was significantly reduced in CK19-positive patients after surgical resection compared with CK19-negative HCC patients, with 26.1% decrease in 1-year survival, 16% decrease in 2-year survival, and 16.4% decrease in 3-year survival, which seriously affected prognosis of the patients (50).