The results showed that the ultrasomics signatures showed satisfactory performance in predicting CK19 expression in HCC patients, and the AUCs of the test dataset and the external validation dataset were 0.789 (95% CI, 0.621 – 0.907) and 0.787 (95% CI, 0.616 – 0.907), respectively. Here, KRT19 is linked to hepatocellular carcinoma.