DDX41 and acute myeloid leukemia: In contrast, little is known about the precise role of DDX41 in RNA splicing, although exon skipping was a major change feature of cells derived from AML patients with DDX41 mutations (4), and splicing changes were also observed in hematopoietic progenitor cells from Ddx41-deficient mice, with exon skipping and retained introns being the major alterations (57).