TGFB1 and neoplasm: In addition, TGFβ1 and TGFβ3 expression were negatively correlated with Mutant-allele tumor heterogeneity (MATH) (Figures 9C–E). We also compared the tumor mutation burden (TMB) between different TGFβ groups and showed that TMB was higher in the TGFβ1, TGFβ2 and TGFβ3 low expression groups (P < 0.05), while higher TMB was beneficial for prolonging patient survival (Figures 9F–I).