The results of the Cox univariate analysis in the TCGA database showed that TGFβ1, TGFβ2 and TGFβ3 were prognostic risk factors in most cancers (BLCA, PAAD, KIRP, LIHC, MESO, COAD, THCA, HNSC, LGG, ACC and UVM), notably TGFβ1, TGFβ2 and TGFβ3 were all poor prognostic factors in STAD. The gene discussed is TGFB3; the disease is bladder transitional cell carcinoma.