To further explore the effect of different TP53 mutation types on SPOP mutations, we divided metastatic PCa patients with SPOP mutation into three cohorts according to TP53 mutation status, namely SPOPmut/TP53wt cohort, SPOPmut/TP53other cohort and SPOPmut/TP53truncating cohort (Figure 7B). Here, TP53 is linked to posterior cortical atrophy.