reveal that CD8+ T cells drive ferroptosis in tumor cells and the tumor suppressive function of interferon (IFN)-gamma secreted by CD8+ T cells in response to immune checkpoint blockade meditated by ferroptosis, suggesting that the immune system may function in part through ferroptosis to prevent tumorigenesis, and ferroptosis may hold the key to tumor immunotherapy response (28, 29). This evidence concerns the gene CD8A and neoplasm.