PRPF8 and cyclic hematopoiesis: Previous research based on large samples found that CH is largely the result of mutations in fixed “early” mutational events: The genes that encode epigenetic modifiers, DNMT3A and TET2, are the two most common mutations; the third most commonly mutated gene was ASXL1, whereas mutations in splicing factors (SF3B1, SRSF2, PRPF8, and U2AF1) were also frequent (72).