NPM1 and acute myeloid leukemia: Several genes are recurrently mutated in AML, such as internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3-ITD), and mutations in isocitrate dehydrogenase (IDH1/2), nucleophosmin (NPM1), and/or CCAAT/enhancer binding protein alpha (CEBPA).