One study demonstrated that the sensitivity and specificity of the gene in stool samples for the detection of CRC were as high as 81 percent and 95 percent, respectively (25).In addition to the above target genes, there are some studies confirming that SDC2 (26, 27), SNCA and FBN1 (28), and can be valuable biomarkers for non-invasive detection of CRC. Here, SNCA is linked to colorectal carcinoma.