Colorectal cancer genome-wide association study reported that genes encoding genes associated with above high risk of colorectal cancer include ATOH1, APOBEC1, BB, BMP5, CDKPN2A, CYP17A1, EIF3H, FKBP5, MED13L, PDLIM5, PTGER4, PTPN1, RTEL1, RPS21, SMARCAD1, SPSB2, TERT or TFEB (75). The gene discussed is RPS21; the disease is colorectal cancer.