Colorectal cancer genome-wide association study reported that genes encoding genes associated with above high risk of colorectal cancer include ATOH1, APOBEC1, BB, BMP5, CDKPN2A, CYP17A1, EIF3H, FKBP5, MED13L, PDLIM5, PTGER4, PTPN1, RTEL1, RPS21, SMARCAD1, SPSB2, TERT or TFEB (75). This evidence concerns the gene PTGER4 and colorectal cancer.