NFKB1 and Cirrhosis: As the study flowchart is shown (Figure 1), a singlelocus multivariate cox proportional hazards regression analysis was first used to evaluate associations between 2,060 SNPs of NF-kB signaling pathway genes and HCC OS with adjustment for age, sex, smoking status, drinking status, AFP level, cirrhosis, embolus and BCLC stage in the discovery dataset.