And Leucine-rich repeat protein 26 (LRRC26), ATP-dependent translocase ABCB1 (ABCB1), Bile salt export pump (ABCB11), Adhesion G protein-coupled receptor G6 (ADGRG6), Desmosomes-1 (DSC1), Desmoglein-1 (DSG1), Keratin and Plasminogen-like protein B (PLGLB1) were present only in plasma-derived EVP in patients with pancreatic cancer (PaCa), absent or extremely low expression in tumor tissue (TT) and adjacent normal tissue (AT) -derived EVP. The gene discussed is PLGLB1; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.