It has been suggested that GPC1-positive exosomal was highly expressed in the serum of pancreatic cancer patients, and the diagnostic power of the exosomal protein GPC1 (AUC = 1.0) was significantly better than CA19-9 (AUC =0.739) in distinguishing pancreatic cancer patients from healthy controls. Here, GPC1 is linked to familial pancreatic carcinoma.