BSG and neoplasm: EMMPRIN is expressed at varying levels widely such as in immune cells, epithelial and endothelial cells (ECs), and tumor cells (32), In the normal mammalian CNS, EMMPRIN is expressed on endothelial cells of the blood-brain barrier, and in other subregions such as the septum, amygdala, thalamic anterior nuclei, hypothalamus, mesencephalic tegmentum, entorhinal cortex, and cingulate gyrus (28, 39, 61).