IL4 and infection: Data extracted from FANTOM5, demonstrating CAGE sequencing of diverse cellular states, showed a significant reduction in Lyl1 expression in all macrophage subsets (unstimulated, M1 (IFNγ stimulated) and M2 (IL-13/IL-4 stimulated) following Mtb HN878 infection in vitro (Figure 1A) (23, 25); while the downregulation was not observed in uninfected macrophages (Supplementary Figure 1A).