Besides, it is not known whether CCL11 (a chemokine for eosinophils, engaging in ovarian cancer progression) (10, 47), CCL21 (a chemokine for thymocytes and activated T cells, mediating homing of lymphocytes) and IL-16 (a modulator of T cell activation) participate in the functionality of CAFs and the remodeling of the tumor immune microenvironment, which might deserve further exploration. This evidence concerns the gene IL16 and neoplasm.