Functionally, ovarian tumor cells activate fibroblasts or induce cancer-associated fibroblasts-phenotype to promote ovarian cancer progression and reduce overall survival by secreting lysophosphatidic acid, interleukin-1β (IL-1β), and C-C motif chemokine ligand 5 (CCL5) (8–10). The gene discussed is CCL5; the disease is ovarian cancer.