To determine if MyD88 transduces LPS/TLR4 signaling to induce cancer apoptosis in the presence of an IAP antagonist, we investigated the effect of a small molecular compound, called 4210, which blocks MyD88 dimerization (42), on the apoptosis of MDA-MB-231 cells induced by LPS+SM-164. Here, TLR4 is linked to cancer.