ScRNA-seq studies revealed that SARS-CoV-2-specific CD8+ T cells during the acute phase of infection expressed genes associated with cytotoxicity (GZMA, GZMK, and PFN1), activation (HLA-DRA, CD38, and PDCD5), proliferation (MKI67, MCM7, and NUDC1), and IFN responses (IFI6, MX1, IFI27L2, and IFI44L), compared with that in the recovery phase (71). The gene discussed is CD8A; the disease is infection.