(2) Shahanshah and colleagues suggest that high glucose can increase the levels of inflammatory cytokines IL-6, TNF-a, Lcn2 (Lcn2), and Cox2 (Ptgs2) by altering gut microbiota composition, mucosal association, and functional activity, thereby aggravating the progression of inflammatory bowel disease (1). This evidence concerns the gene PTGS2 and inflammatory bowel disease.