And we noticed significant variation in the distribution of the widely accepted 5 intrinsic molecular subtypes of breast cancer (Luminal A, Luminal B, HER2-enriched, Basal-like and Claudin-low) among the three LR pairs-based subtypes, in which the claudin-low subtype samples accounted for a large proportion of the C3 subtype, and the basal subtype samples accounted for a large proportion of the C1 subtype. Here, ERBB2 is linked to breast cancer.