Viral protein interaction with cytokine and cytokine receptor, cytokine−cytokine receptor interaction, cell adhesion molecules (CAMs), chemokine signaling pathway, intestinal immune network for IgA production, rheumatoid arthritis, proteoglycans in cancer, malaria, neuroactive ligand−receptor interaction and hematopoietic cell lineage were the 10 most highly enriched pathways of 145 LR pairs (Figure 1D). The gene discussed is IL18R1; the disease is cancer.