Animal models with chronic trichuriasis have evidence of transmural colonic inflammation and immune profiles dominated by proinflammatory mediators interferon (IFN)-γ, interleukin (IL)-1β, STAT4, tumor necrosis factor (TNF)-α, and IL-6, mimicking both murine models of inflammatory bowel disease and human inflammatory bowel disease (40). The gene discussed is TNF; the disease is inflammatory bowel disease.