TLR8 and pure red-cell aplasia: In addition to TLR8-GOF, LGL cells can be found in several BMF entities, including severe aplastic anemia (SAA), paroxysmal nocturnal hemoglobinuria, and pure red cell aplasia (PRCA), as well as in autoimmune diseases (ALPS, RA/FS), hematopoietic malignancies, and plasma cell disorders (32–34).