While this homeostasis pathway in patients with TLR8-GOF remains undetermined, Fas/FasL homeostasis invites further scrutiny, considering that several of the TLR8-GOF patients were considered to have ALPS at some point in their disease course and displayed DNT cells, elevated soluble vitamin B12, and FasL levels (16). The gene discussed is FAS; the disease is autoimmune lymphoproliferative syndrome.