TLR8 and Bone marrow hypocellularity: The discovery of TLR8-GOF mutations will be used to frame this interface and show examples of approaches into the interface by entities that are more or less defined by bone marrow failure with concomitant autoimmune cytopenias (coming from the “H/O territory’) and entities with autoimmune cytopenias that also may be associated with bone marrow failure (coming from the A/I-rheumatology territory).