STAT3-associated sensitivity to BH3 mimetics has been observed in STAT3-GOF disease as well while in a potentially new addition to the interface; inherited PD-1 deficiency, a disorder characterized by mycobacterial infections, lymphoproliferation and autoimmunity, as well as abnormal STAT3 signaling, but without STAT3 mutations (43, 44). The gene discussed is STAT3; the disease is Autoimmunity.