For example, while the disorders autoimmune lymphoproliferative syndrome (ALPS) (see the list of abbreviations) and LPS responsive beige-like anchor protein (LRBA) deficiency cause cytopenias due to autoantibody-mediated peripheral destruction, their molecular basis is different: ALPS is a disorder of defective apoptosis, while LRBA deficiency can be considered a so-called “Tregopathy” (disorder involving defective T regulatory T cells). Here, LRBA is linked to autoimmune lymphoproliferative syndrome.