The innate immune system includes several important NSs, including cyclic guanosine-monophosphate adenosine-monophosphate synthase (cGAS), absent in melanoma 2 (AIM2) and Toll-like receptor 9 (TLR9) that sense DNA fragments, and RIG-I like receptors (RLRs), nucleotide-binding oligomerization domains (NODs), Toll-like receptor 3 and 7 (TLR3 and TLR7) that sense RNA fragments (1, 2). Here, TLR9 is linked to melanoma.