SPP1 and Sepsis: Figure 3 shows that results mirrored those shown in Fig.2: CLP-induced sepsis caused striking increase of ALT, AST, creatinine and urea levels in WT type mice, and these levels were decreased by treatment with ICOS-Fc, but not F119SICOS-Fc. Levels of these markers were increased also in CLP ICOS-/- and ICOSL-/- mice and urea levels were even higher in ICOS-/- than in WT mice. In CLP ICOS-/- mice, treatment with ICOS-Fc significantly decreased all these markers. In CLP OPN-/- mice, levels of these markers were significantly lower than in CLP WT mice.