DNA methyltransferases DNMT3B, DNMT3A, and DNMT1 were comparatively overexpressed in the MS4A6A high expression subgroup, which might be the reason for MS4A6A hypomethylation in glioma tissues, leading to insight into upregulated mechanisms of MS4A6A in glioma. The gene discussed is DNMT1; the disease is central nervous system cancer.