CD163 and central nervous system cancer: After adjustment based on glioma purity, MS4A6A remained notably related to the majority of signatures of immune cells, particularly macrophages (GBM: CD68: ρ = 0.623, p < 0.001; LGG: CD68: ρ = 0.805, p < 0.001) and M2 macrophages (GBM: CD163: ρ = 0.591, p < 0.001; LGG: CD163: ρ = 0.750, p < 0.001) (Table 2).