Upon meeting with the stimulation of IL-25, nuclear transcription factor kappa B activator 1 (Act 1) binds to IL-17RB and then mediates the secretion of IL-5 and IL-13, which participates in the development of allergic diseases, via recruiting and activating eosinophils and stimulating the production of immunoglobulin E (IgE) (16–20). The gene discussed is IL25; the disease is allergic disease.