IL-25 strongly activates ILC2, which rapidly secretes IL-25 and results in a positive feed-back loop upon Ft infection, and the administration of IL-25 notably increases IgM production in mice; antibody-mediated depletion of ILC2 mainly supports the source of IL-5, which is required for IgM production; therefore, discovering the IL-25-ILC2-IL-5 axis is a novel strategy to improve vaccination depending on the IL-17RB signal pathway (109). The gene discussed is CD40LG; the disease is infection.