P2RY2 and breast cancer: Hana Jin and Hye Jung Kim (126) determined that NLRC4 inflammasome regulated by tumor necrosis factor-α (TNF-α) or ATP dependent on P2Y2R is engaged in breast cancer cells invasion and angiogenesis Moreover, breast cancer patients who are obese tend to have more myeloid cells that infiltrate tumors, which activated NLRC4 and mature IL-1β.