So far, there are six categories of human gasdermins classified based on the difference in the conserved domain: gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), GSDMD, GSDME/DFNA5 (deafness, autosomal dominant 5)), and DFNB59/Pejvakin) (22). This evidence concerns the gene GSDME and deafness.