It has been proven that the level of NLRP3 was aberrantly high in the microenvironment and the NLRP3 activation enhanced tumorigenesis and metastasis as well as the invasion of myeloid cells like tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) in breast cancer orthotopic models (118). The gene discussed is NLRP3; the disease is neoplasm.