In NPC patients, the uptake of 18F-FDG (18F-fluorodeoxyglucose) into NPC lesions was positively correlated with PD-L1 expression in TCs (36), the expression of PD-L1 in TC is positively correlated with T staging (37), and high PD-L1 expression is significantly associated with poor OS (38, 39) and DFS (40–42). This evidence concerns the gene CD274 and nasopharyngeal carcinoma.