CD274 and neoplasm: In NPC, the uptake of 18F-FDG (18F-fluorodeoxyglucose) into NPC lesions was negatively correlated with PD-L1 expression in tumor infiltrating immune cells (TIICs) (36), PD-L1 expression on TIL was negatively correlated with plasma EBV (Epstein-Barr virus) DNA load, N staging, M staging and clinical staging (37); It was also associated with significantly improved 1 and 2-year survival rates (75), and was positively correlated with the 5-year PFS rate (76).