It was observed that inhibition of TLR4 (as opposed to TLR2) in Nr1i2-/- mice could decrease TNF-α and IL-6 levels, which is consistent with the result that Pxr-/-Tlr4-/- mice (compared with Pxr-/-Tlr2-/- mice) could effectively protect against Listeria monocytogenes infection (53) (Figure 2). The gene discussed is TLR4; the disease is listeriosis.