NR1I2 and metabolic dysfunction-associated steatotic liver disease: Moreover, the increased expression of PXR in high-fat diet-treated mice (41), as well as the high levels of NLRP3 inflammasome in macrophages in NAFLD (42), suggested a feedback loop in which NAFLD microenvironments upregulated the expression of PXR and its downstream activation of NLRP3 inflammasome in macrophages, aggravating the severity of NAFLD.