NR1I2 and infection: It has been demonstrated that crosstalk between PXR and several innate immune signalings such as NF-κB, TLRs, and inflammasomes contributed to PXR-modulated innate immune responses, which further facilitated the adaptative immune responses to infections caused by microbes such as bacteria (14–16), viruses (17, 18), fungi (19, 20), and parasites (21, 22).