While 100% of rASP-1-adjuvanted IIV3 immunized WT mice survived the H1N1 i.n. viral challenge (7500TCID50) (Figures 8A, F), the TLR4-/-, TRIF-/-, and IFNAR-/- immunized mice succumbed to the infection (Figures 8B–D, G–I). Here, TICAM1 is linked to infection.