TLR4 and infection: While 100% of rASP-1-adjuvanted IIV3 immunized WT mice survived the H1N1 i.n. viral challenge (7500TCID50) (Figures 8A, F), the TLR4-/-, TRIF-/-, and IFNAR-/- immunized mice succumbed to the infection (Figures 8B–D, G–I).