The safety of the recombinant viruses was tested in 1-month-old lambs and results demonstrated that no ORFV associated symptoms such as ulcer and proliferative scabby lesions were induced by either rGS14-ΔCBP, rGS14-ΔGIF or rGS14-ΔCBP-ΔGIF at 21 days post-infection. This evidence concerns the gene RGS14 and infection.