Recently, we performed the first genetic research in the Chinese CRS cohort, which sequenced 17 genes known to be associated with CRS, including FGFR2, FGFR3, TWIST1, EFNB1, TCF12, SKI, RAB23, FGFR1, TGFBR2, POR, SMAD3, ERF, TGFBR1, MSX2, RECQL4, TGFB2, IFT43 (Wu et al., 2021). The gene discussed is POR; the disease is congenital rubella syndrome.