Recently, we performed the first genetic research in the Chinese CRS cohort, which sequenced 17 genes known to be associated with CRS, including FGFR2, FGFR3, TWIST1, EFNB1, TCF12, SKI, RAB23, FGFR1, TGFBR2, POR, SMAD3, ERF, TGFBR1, MSX2, RECQL4, TGFB2, IFT43 (Wu et al., 2021). This evidence concerns the gene RECQL4 and congenital rubella syndrome.