EVC2 and Ellis Van Creveld syndrome: We found two sagittal patients, case W015 and W038, carried heterozygous missense variants in EVC. To date, only a single case of sagittal synostosis has been reported in a patient affected by Ellis-van Creveld syndrome, but this disorder is usually caused by homozygous variants in either the EVC or EVC2 genes (Fischer et al., 2015; Tiberio et al., 2021).