Of all these hub genes, CBLN1 (AUC = 0.924), DNAH5 (AUC = 0.867), HMOX1 (AUC = 0.971), SLC26A8 (AUC = 0.933), and LOC100507250 (AUC = 0.848) were highly predictive of the occurrence and development of PCOS (Figure 3C). The gene discussed is HMOX1; the disease is polycystic ovary syndrome.