Recently, Yan et al. reported that NSUN2 is an important intermediate element that was recruited to FOXC2 mRNA by FOXC2-AS1 (one kind of long noncoding RNA) to increase the m5C level of the mRNA and repress its degradation, thereby, elevating the expression of FOXC2-AS1 and advance TNM stage and shorten overall survival in gastric cancer patients (Yan et al., 2021). The gene discussed is FOXC2; the disease is gastric cancer.