Notably, some of the hub genes including HLA-DQA1, CIITA, CD69, and CYBB, have previously been reported to be involved in asthma (Movahedi et al., 2008; Lasky-Su et al., 2012; Ökrös et al., 2012; Bae et al., 2013; Kwon et al., 2021). This evidence concerns the gene HLA-DQA1 and asthma.