Moreover, after performing multivariate COX regression analysis, WT1, HOXA2, HOXC6, MMP9, SHOX2 and MYOD1 were selected to establish a predictive signature for glioma patients in the training cohort TCGA with a risk score = (0.044 × WT1 expression) + (0.062 × HOXA2 expression) + (0.122 × HOXC6 expression) + (0.074 × MMP9 expression) + (0.140 × SHOX2 expression) + (-0.205× MYOD1 expression). This evidence concerns the gene MMP9 and central nervous system cancer.