It is also known that poorly controlled hypertension is a major risk factor for TBAD, and our study demonstrated that the ULK4 gene, involved in endocytosis and axon growth (Ostberg et al., 2020), is associated with age of first onset of TBAD, suggesting that in addition to the association with the control of hypertension, genomic variants in ULK4 have a potential mechanism for contributing to the early onset of TBAD. This evidence concerns the gene ULK4 and Hypertension.