Of particular interest were the seven significant TWAS-identified common genes associated with CeD found in all four tissues, which included five novel genes (TCF19, AP3S2, HEATR3, GSDMB, and POLI) and two genes within previously GWAS-identified CeD loci (HLA-DQA1 (Coleman et al., 2016) and MICB (González et al., 2004)). This evidence concerns the gene HEATR3 and cranioectodermal dysplasia.