Neurodegenerative diseases occur more frequently in patients with inflammatory gastrointestinal diseases including IBD or CeD, while ASAH2 has been discovered in Parkinson’s disease (Blokhin et al., 2022) and Alzheimer’s disease (Avramopoulos et al., 2007). The gene discussed is ASAH2; the disease is early-onset autosomal dominant Alzheimer disease.