As a result, ABCC1, ANO6, IDH1, IREB2, PANX1, SOCS1, TNFAIP3, CBS, CDKN1A, LAMP2, SRC, FTH1 and PTGS2 were significantly upregulated, while ALOX15, MAPK3, AKR1C3, MUC1, NQO1 were significantly downregulated in NPC. The gene discussed is IREB2; the disease is nasopharyngeal carcinoma.