Studies have reported that activation of NF-κB pathway and cell cycle inhibitors played an important role in NPC (Zheng et al., 2016; Li et al., 2017; Wang et al., 2017) and deletion of several NF-κB and cell cycle inhibitors were found such as CDKN2A, CDKN2B, CYLD and TRAF3 (Zhang et al., 2017). This evidence concerns the gene CYLD and nasopharyngeal carcinoma.