The protein regulator of cytokinesis 1 (PRC1) has been shown to exert an oncogenic function by promoting tumor formation, transfer, stemness, and progression of early HCC through the Wnt/β-catenin signaling pathway modulation, and its overexpression has been linked to poor HCC patient survival (Chen et al., 2016; Wang et al., 2017). This evidence concerns the gene PRC1 and hepatocellular carcinoma.