Contrastingly, Du et al. (2019) noticed a significant overexpression of miR-3691-5p in HCC tissues and cell lines substantially linked to clinicopathological characteristics such as TNM stage and vascular invasion through activating PI3K/Akt signaling by targeting PTEN, and they considered this miRNA as an HCC oncomiR. This evidence concerns the gene PTEN and hepatocellular carcinoma.