USP22 and hepatocellular carcinoma: Likewise, Xin R. Q. et al. (2020) showed that USP22, a histone-modifying enzyme principally regulated by miR-329-3p (normally downregulated in HCC), is linked to distant metastasis, poor prognosis, and high recurrence rates in HCC since it critically modulates the proliferation, metastasis, DNA repair, and stemness of tumor cells via modulating Wnt/β-catenin pathway.