While in another study, WW domain-binding protein 2 (WBP2) was reported to interrelate with various WW domain-containing proteins, including WW domain-containing transcription regulator protein 1 (TAZ) and WW domain-containing oxidoreductase (WWOX), and favorably linked with the Wnt/β-catenin signaling pathway to promote downstream gene transcription, resulting in HCC progression (Chen et al., 2017). This evidence concerns the gene WWOX and hepatocellular carcinoma.