As opposite, an association study including nearly 80 000 subjects reported various PON1 polymorphisms to be correlated with both arylesterase and paraoxonase PON1 activities, but no correlation was reported between the PON1 polymorphisms and a history of cardiovascular disease or the 3 year risk of MACE (Tang et al., 2012). The gene discussed is PON1; the disease is cardiovascular disorder.