Functional enrichment analysis revealed 10 hub genes mainly centered on biological processes (BP), such as cytokine-mediated signaling pathway, regulation of signaling receptor activity, cellular response to cytokine stimulus, response to cytokine, while KEGG was mainly focused on IL-17 signaling pathway, Rheumatoid arthritis, TNF signaling pathway, Cytokine-cytokine receptor interaction and NF-kappa B signaling pathway (Figures 5A,B; Table 4). This evidence concerns the gene TNF and rheumatoid arthritis.