In previous studies, mir-335-5p has been found to inhibit the inflammatory response in chronic rhinosinusitis (Gu et al., 2020); and moreover mir-335-5p could alleviate the inflammatory response and airway fibrosis by modulating ATG5, resulting in relief of childhood asthma (Liang et al., 2022). This evidence concerns the gene ATG5 and childhood onset asthma.