GO term analysis showed that these 10 genes were highly enriched in cytokine-mediated signaling pathway, regulation of signaling receptor activity, cellular response to cytokine stimulus, response to cytokine, while KEGG pathway analysis were mainly enriched IL-17 signaling pathway, Rheumatoid arthritis, TNF signaling pathway, Cytokine-cytokine receptor interaction and NF-kappa B signaling pathway. The gene discussed is TNF; the disease is rheumatoid arthritis.