Spearman correlation analysis showed that FOXQ1 expression was related to the TMB in 14 tumors, with FOXQ1 expression positively correlated with the TMB in cholangiocarcinoma, colon adenocarcinoma, esophageal carcinoma, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, mesothelioma, pancreatic adenocarcinoma, and thyroid carcinoma and negatively correlated with the TMB in liver hepatocellular carcinoma, lung adenocarcinoma, ovarian serous cystadenocarcinoma, prostate adenocarcinoma, skin cutaneous melanoma and uterine corpus endometrial carcinoma (Figure 8A). The gene discussed is FOXQ1; the disease is cutaneous melanoma.