JAK2 and colorectal cancer: The role of FOXQ1 in immunology has been preliminarily confirmed, with previous research showing that cancer-related macrophages induce epithelial–mesenchymal transition by regulating the JAK2/STAT3/miR-506-3p/FOXQ1 axis, thereby enhancing the invasion and migration of colorectal cancer cells (Wei et al., 2019).