Cox proportional risk regression analysis was performed on the candidate genomic instability-associated lncRNAs in the training set, and a genomic instability-associated lncRNAs signature (GILncSig) consisting of 5 lncRNAs with independent prognostic value (AL121772.1, BX640514.2, LINC01133, AC087752.3, and LYPLAL1-AS1) was established to predict the prognosis of PC. This evidence concerns the gene LYPLAL1 and pachyonychia congenita.