AIM2 response to dsDNA and then induce AIM2-dependent release of IL-18 and IL-1β, which plays a critical role as a trigger of autoimmune diseases, including psoriasis (Dombrowski et al., 2011), systemic lupus erythematosus (Shin et al., 2019), primary Sjogren’s syndrome (Vakrakou et al., 2020). The gene discussed is AIM2; the disease is psoriasis.