Recent studies have found that certain factors regulate the AIM2 inflammasome signaling pathway and participate in the pathogenesis of psoriasis, including prokineticin 2 (PK2), caspase recruitment domain family member 18 (CARD18), aurora kinase A (AURKA), TLR-7, TLR-8, and TLR-9 antagonists. The gene discussed is CARD18; the disease is psoriasis.