AIM2 gene plays the tumor-suppressive role in HPV-infected cervical cancer (So et al., 2018), breast cancer (Yoon et al., 2015), squamous cell carcinoma (Farshchian et al., 2017); while AIM2 gene is regarded as a protective factor in melanoma (DeYoung et al., 1997; de Koning et al., 2014) and colorectal cancer (Wilson et al., 2015; Zhang Z. et al., 2017). Here, AIM2 is linked to squamous cell carcinoma.