AIM2 response to dsDNA and then induce AIM2-dependent release of IL-18 and IL-1β, which plays a critical role as a trigger of autoimmune diseases, including psoriasis (Dombrowski et al., 2011), systemic lupus erythematosus (Shin et al., 2019), primary Sjogren’s syndrome (Vakrakou et al., 2020). Here, AIM2 is linked to autoimmune disease.