Quaking I-5 (QKI-5), RALY heterogeneous nuclear ribonucleoprotein (RALY), and KH-type splicing regulatory protein (KHSRP) promote cancer cell proliferation and invasion, and they are associated with OS probability in NSCLC (Yan et al., 2019; Liang et al., 2020a; Song et al., 2020). The gene discussed is KHSRP; the disease is cancer.