Consistently, Cui et al. (2021) recently demonstrated that neutrophil-derived active neutrophil elastase (ELANE) not only kills numerous types of cancer cells while sparing proximal non-cancer cells by liberating the CD95 death domain that interacts with histone H1 isoforms, but also inhibits metastasis via CD8+T mediated abscopal effect. Here, H1-0 is linked to cancer.