CASP8 and cancer: Hou et al. (2020) showed GSDMC mediated non-canonical pyroptosis upon caspase-8 activation and that high GSDMC expression correlated with poor survival. It is difficult to thoroughly elucidate the role of IL18 in cancer. A high level of IL18 in pancreatic tumor tissue was associated with a shorter survival time, increased invasion, and metastasis, whereas a high IL18 level in plasma was correlated with a longer survival time (Guo et al., 2016).