PXDN and oral cavity squamous cell carcinoma: PXDN also has an essential role in accelerting various cancer types, such as oral squamous cell carcinoma (OSCC), melanoma, prostate cancer (PCa) and ovarian cancer (OC) (Zheng and Liang, 2018; Dougan et al., 2019; Kurihara-Shimomura et al., 2020; Paumann-Page et al., 2021).