AKT1 and colorectal cancer: A study in colorectal cancer showed that downregulation of Linc00996 expression is strongly linked with the tumorigenesis, metastasis, and poor prognosis, indicating that Linc00996 directly participates in or indirectly regulates pivotal genes in the JAK-STAT and PI3K-AKT and other signaling pathways, thereby affecting the tumorigenesis and critical transfer pathways of colorectal cancer (Ge et al., 2018).