There are many studies on the relationship between AGEs and AD, and the main mechanisms leading to the pathogenesis may be as follows: AGEs can lead to the occurrence and development of AD through a variety of ways, such as modifying Aβ and Tau proteins, triggering inflammatory responses, causing mitochondrial dysfunction, producing oxidative stress damage and affecting cell metabolism, the cycle of neurons, autophagy, and the permeability of the blood-brain barrier, etc. [19]. Here, MAPT is linked to Alzheimer disease.