Signaling pathways such as the phosphoinositide 3 kinase/AKT (PI3K/AKT) signaling pathway, signal transducer and activator of transcription 3 (STAT3) signaling pathway, and mitogen-activated protein kinases (MAPK) signaling pathway are important in the pathological process of pancreatic cancer and are frequently activated in pancreatic cancer. Here, STAT3 is linked to familial pancreatic carcinoma.