Signaling pathways such as the phosphoinositide 3 kinase/AKT (PI3K/AKT) signaling pathway, signal transducer and activator of transcription 3 (STAT3) signaling pathway, and mitogen-activated protein kinases (MAPK) signaling pathway are important in the pathological process of pancreatic cancer and are frequently activated in pancreatic cancer. This evidence concerns the gene WNK2 and pancreatic neoplasm.