TNF and prion disease: Alcanivorax and Alcanivorax venustensis were shown to have significant positive correlations with 5 candidate pathways (TNF signaling pathway, Staphylococcus aureus infection, ECM-receptor interaction, Prion disease, and Hematopoietic cell lineage) (Adjusted P < 0.05, Spearman rho > 0.7).