TNF and prion disease: The results revealed that 8 candidate signaling pathways were identified for which the enrichment scores were increased due to model treatment but restored by the IP6 supplement, namely Cytokine-cytokine receptor interaction, TNF signaling pathway, Chagas disease, IL-17 signaling pathway, Staphylococcus aureus infection, ECM-receptor interaction, Prion disease, and Hematopoietic cell lineage (p < 0.05, Figure 3C).