APOE and colonic neoplasm: ABCC2, VNN1, and APOE were also DE in the duodenum together with DUSP18, GPRC5A, and ANGPTL4. Vanin-1 (VNN1) induces oxidative stress in colon cancer cells, and it is stimulated by the expression of G protein-coupled receptor class C group 5 member A (GPRC5A) (81).